Senior Scientist
Insmed Incorporated

Company Description

Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.

Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career.

Recognitions

Named Science's Top Employer in 2021, 2022, and 2023

Insmed is dedicated to creating a collaborative environment where our team can thrive. Every day, our employees turn their passion for science and research into innovative solutions for patients. That's why we were named the No. 1 company to work for in the biopharma industry in Science's Top Employers Survey for two years in a row.

A Certified Great Place to Work

We believe our company is truly special, and our employees agree. In July 2023, we became Great Place to Work-certified in the U.S. for the third year in a row. We are also honored to have been listed on the Best Workplaces in Biopharma™, Best Workplaces in New York™, and Best Workplaces for Millennials™ lists.

Overview

Applicant should be a highly motivated and experienced Mass Spectrometry expert. In this role, the candidate will play a key role in elucidating the mechanism of action and identifying biomarkers for our novel protein inhibitors and therapeutics. The candidate will utilize advanced mass spectrometry techniques to analyze changes in the cellular environment following inhibitor or therapeutic treatment. This will involve identifying potential small molecule and protein-based biomarkers associated with inhibitor activity, which could ultimately contribute to the development of new therapeutics by providing a deeper understanding of the drug's impact on the cellular environment.

Responsibilities

Responsibilities:

• Develop and implement mass spectrometry methods to analyze protein-ligand interactions between the inhibitor or therapeutic and its target protein.
• Design and execute experiments to identify and characterize changes in the metabolome and proteome following inhibitor treatment of relevant biological samples (e.g., cells, plasma, tissues).
• Develop and validate methods for the identification and quantification of potential small molecule and protein-based biomarkers associated with therapeutic activity.
• Utilize bioinformatic tools for data interpretation to identify relevant metabolites, proteins, and potential biomarkers.
• Collaborate with scientists in other groups to ensure proper experimental design and interpretation of results.
• Prepare and present research findings internally and at scientific meetings and contribute to the publication of research articles.
• Stay up-to-date with the latest advancements in mass spectrometry technology and its application in drug discovery, particularly in metabolomics and proteomics.

Qualifications:

• PhD in Biochemistry, Chemistry, or a related field with a strong focus on metabolomics and proteomics analysis using mass spectrometry.
• Minimum 5+ years of hands-on experience in applying advanced mass spectrometry techniques for both metabolomics and proteomics.
• Experience with LC-MS maintenance and troubleshooting.
• Strong understanding of cellular processes and the impact of protein inhibition on the metabolome and proteome.
• Excellent written and verbal communication skills.
• Strong work ethic, self-motivation, and a collaborative spirit.
• Experience with documentation of scientific data, scientific writing and publishing research findings.
• Strict adherence to environmental, health, and safety guidelines.

Strong understanding of cellular processes and the impact of protein inhibition on the metabolome and proteome. Excellent written and verbal communication skills.Strong work ethic, self-motivation, and a collaborative spirit.Experience with documentation of scientific data, scientific writing and publishing research findings.Strict adherence to environmental, health, and safety guidelines.

Travel Requirements

up to 5% travel

Salary Range

Insmed takes into consideration a combination of candidate's education, training, and experience as well as the position's scope and complexity, the discretion and latitude required in the role, and external market and internal value when determining a salary level for potential new employees.

The base salary range for this job is from $115,000.00 to $161,867.00 per year

Compensation & Benefits

We're committed to investing in every team member's total well-being, now and in the future. We offer a competitive total-rewards package to all employees around the world, including:

• Flexible approach to where and how we work, regionally based
• Competitive compensation package including bonus
• Stock options and RSU awards
• Employee Stock Purchase Plan (ESPP)
• Flexible Vacation Policy
• Generous paid holiday schedule and winter break

ADDITIONAL U.S. BENEFITS:

• 401(k) plan with company match
• Medical, dental, and vision plans
• Company-provided Life and Accidental Death & Dismemberment (AD&D) insurance
• Company-provided short and long-term disability benefits
• Unique offerings of pet, legal, and supplemental life insurance
• Flexible spending accounts for medical and dependent care
• Accident and Hospital Indemnity insurance
• Employee Assistance Program (EAP)
• Mental Health on-line digital resource
• Well-being reimbursement
• Paid leave benefits for new parents
• Paid time off to volunteer
• On-site, no-cost fitness center at our U.S. headquarters

Additional Information

Insmed Incorporated is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.

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